Natural Killer (NK) cells are key for the limitation and reversion of precancerous tissue fibrosis as well as for cancer immune surveillance, due to unique cytotoxic properties. Recent results of Prof. Christian Stockmann's research group indicate that HIF-transcription factors are pivotal for NK cell immune surveillance. Based on NK cell-specific loss and gain of function approaches for HIFs, this SNF project will elucidate the role of HIFs for NK cell function. Manipulating the HIF pathway in NK cells has the potential to be a novel therapeutic target in organ fibrosis and cancer.
