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Institute of Anatomy

"The transcription factor HIF-1α mediates plasticity of NKp46+ innate lymphoid cells in the gut"

The group of Prof. Christian Stockmann published successfully their work on the role of the transcription factor HIF-1α in defining the phenotype of gut innate lymphoid cells (ILCs). Those cells of the innate immune system show a surprisingly high diversity and are crucial for gut homeostasis. In their studies, Krzywinska E., Sobecki M., et al. could demonstrate the crucial role of HIF-1α in ILC function, lipid metabolism, and gut defense. Their experimental results hints to new therapeutic targets in inflammatory bowel disease or metabolic disorders.