Fibrosis is a pathological proliferation of connective tissue that destroys the healthy tissue. It is the ultimate consequence of almost every kind of chronic damage. Fibrosis can occur in almost every type of tissue in the body, although the liver, lungs, heart and kidneys are most often affected. Fibrosis is responsible for up to 45 percent of all mortality in industrialized countries. The project aims to develop a new strategy to eliminate fibroblasts in a targeted manner by eliciting an immune response similar to that to a vaccination, in which the activated connective tissue cells are destroyed while the resting fibroblasts are left unharmed. The project funding will run for four years starting on January 1, 2023.