The filtration activity of the kidney significantly determines the proteome in the blood plasma. Moreover, the blood and urine concentration of endogenous proteins are used as clinical biomarkers for kidney diseases or malfunctions. The group of Prof. Andrew Hall used up-to-date microscopy and image analysis techniques to elucidate in vivo renal protein metabolism and its spatial and temporal organization. The results stronlgy indicate that the range of usual urinary biomarkers should be expanded to markers of protein degradation.
This work is a result of a collaboration with the UZH Center for Microscopy and Image Analysis and Marine Berquez, PhD, from the UZH Institute of Physiology.
The open access publication can be found here.